Papers and publications

Increasing RSV PICU admissions after large-scale introduction of high flow nasal cannula

Linssen RS, Bem RA, Kapitein B, Rengerink KO, Otten MH, den Hollander B, Bont L, van Woensel JBMHigh flow oxygen intends to decrease work of breathing and prevent respiratory failure. Despite trials have shown benefit, high flow oxygen has not brought the success hoped for as it did not decrease the need for PICU admissions. This study studied trends in 15,606 pediatric intensive care unit (PICU) admissions for (RSV) bronchiolitis in The Netherlands, France, Scotland, Belgium, Italy and Norway b […]

read more

How to use potential RSV preventive interventions wisely? A modelling study on seasonal-approaches of maternal vaccination and passive immunization

Li Y, Hodgson D, Wang X, Atkins KE, Feikin DR, Nair HAs soon as the temperature goes down by the end of summer and the beginning of fall, viruses are lurking around the corner. RSV is also such a virus, which has a clear seasonality in most countries. Maternal vaccination and passive immunization approaches for RSV are currently in development in clinical trials. However, both preventive measures will only offer an infant protection for approximately 3 to 5 months. Timing these defensive strateg […]

read more

Sustainable response to DS-Cav1 in healthy volunteers

Ruckwardt TJ, Morabito KM, Phung E, Crank MC, Costner PJ, Holman LA, Chang LA, Hickman SP, Berkowitz NM, Gordon IJ, Yamshchikov GV, Gaudinski MR, Lin B, Bailer R, Chen M, Ortega-Villa AM, Nguyen T, Kumar A, Schwartz RM, Kueltzo LA, Stein JA, Carlton K, Gall JG, Nason MC, Mascola JR, Chen G, Graham BS, VRC 317 study team The Vaccine Research Center of NIH published a randomized, open-label, dose-escalation phase 1 clinical trial of the DS-Cav1 stabilized pre-F subunit vaccine. 95 healthy adu […]

read more

Outpatient burden of RSV infection in newborns

Thomas E, Mattila JM, Lehtinen P, Vuorinen T, Waris M, Heikkinen T​RSV is the number one cause of hospitalization for acute lower respiratory tract infection in infants. Moreover, RSV affects an even bigger group of non-hospitalized children. Thomas and his colleagues decided to investigate the burden of RSV infection in this under-recognized patient group. They prospectively followed 408 newborns in Finland during their first RSV season. Throughout this period, one third of the participan […]

read more

Reduction of COVID-19 and related public health measures may inflict a rise in RSV infection

Foley DA, Yeoh DK, Minney-Smith CA, Martin AC, Mace AO, Sikazwe CT, Le H, Levy A, Moore HC, Blyth CC During the current COVID-19 pandemic, RSV infections have fallen of the radar. We have seen a tremendous decrease in RSV infection rates, which usually peak during the fall and winter seasons. This raises the question: what is going to happen when COVID-19 cases decline and public health measures are reduced? Foley and his colleagues highlight the situation in Western Australia in their lett […]

read more

Adenovirus vector containing RSV pre-F induces neutralizing antibodies

Sadoff J, De Paepe E, DeVincenzo J, Gymnopoulou E, Menten J, Murray B, Bastian AR, Vandebosch A, Haazen W, Noulin N, Comeaux C, Heijnen E, Eze K, Gilbert A, Lambkin-Williams R, Schuitemaker H, Callendret BJanssen Pharmaceuticals has shown that a single intramuscular injection with an adenovector (Ad26) -based RSV vaccine is highly immunogenic and able to induce a six-fold increase in RSV A2 neutralizing antibody titers. Viral replication upon RSV A challenge at day 28 after immunization was […]

read more

RSV as a cause of ARDS

Ghazaly MMH, Faddan NHA, Raafat DM, Mohammed NA, Nadel SSepsis, trauma, burn, and transfusion related lung injury are known causes of pediatric ARDS, an alveolar disease leading to hypoxemia. Viral respiratory infection has been mentioned as a more rare cause of ARDS, but the role of individual viruses, such as RSV, is understudied. This single-center retrospective observational study shows that acute viral bronchilitis is an important cause of pediatric acute respiratory distress syndrome in ch […]

read more

Publications Archive

Find older publications in our publications archive.