Papers and publications

Outpatient burden of RSV infection in newborns

Thomas E, Mattila JM, Lehtinen P, Vuorinen T, Waris M, Heikkinen T​RSV is the number one cause of hospitalization for acute lower respiratory tract infection in infants. Moreover, RSV affects an even bigger group of non-hospitalized children. Thomas and his colleagues decided to investigate the burden of RSV infection in this under-recognized patient group. They prospectively followed 408 newborns in Finland during their first RSV season. Throughout this period, one third of the participan […]

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Reduction of COVID-19 and related public health measures may inflict a rise in RSV infection

Foley DA, Yeoh DK, Minney-Smith CA, Martin AC, Mace AO, Sikazwe CT, Le H, Levy A, Moore HC, Blyth CC During the current COVID-19 pandemic, RSV infections have fallen of the radar. We have seen a tremendous decrease in RSV infection rates, which usually peak during the fall and winter seasons. This raises the question: what is going to happen when COVID-19 cases decline and public health measures are reduced? Foley and his colleagues highlight the situation in Western Australia in their lett […]

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Adenovirus vector containing RSV pre-F induces neutralizing antibodies

Sadoff J, De Paepe E, DeVincenzo J, Gymnopoulou E, Menten J, Murray B, Bastian AR, Vandebosch A, Haazen W, Noulin N, Comeaux C, Heijnen E, Eze K, Gilbert A, Lambkin-Williams R, Schuitemaker H, Callendret BJanssen Pharmaceuticals has shown that a single intramuscular injection with an adenovector (Ad26) -based RSV vaccine is highly immunogenic and able to induce a six-fold increase in RSV A2 neutralizing antibody titers. Viral replication upon RSV A challenge at day 28 after immunization was […]

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RSV as a cause of ARDS

Ghazaly MMH, Faddan NHA, Raafat DM, Mohammed NA, Nadel SSepsis, trauma, burn, and transfusion related lung injury are known causes of pediatric ARDS, an alveolar disease leading to hypoxemia. Viral respiratory infection has been mentioned as a more rare cause of ARDS, but the role of individual viruses, such as RSV, is understudied. This single-center retrospective observational study shows that acute viral bronchilitis is an important cause of pediatric acute respiratory distress syndrome in ch […]

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